BRCA1 and cancer: We then estimated how much the posterior probability is affected by whether or not clinical information such as pathologic profiles or personal/family cancer history exists, with specific focus on BRCA2, c.7522G>A, p.(Gly2508Ser) (Figure 2e, Table S10) and BRCA1, c.5339T>C, p.(Leu1780Pro) (Figure 2f, Supplementary Table S11).