The lifetime cumulative risk of breast cancer for BRCA2 carriers was similar to that of BRCA1. It was 58.3% (95% CI: 43.2–73.0%), and there were also differences in the risk by region: 76.1% (95% CI: 42.8–96.0%) in region 1 (~c.2830, BCCR), 43.4% (95% CI: 22.4–69.8%) in region 2 (c.2831 to c.6401, OCCR), and 60.0% (95% CI: 37.5–81.1%) in region 3 (c.6402~, BCCR) (Figure 4c, Supplementary Table S14). The gene discussed is BRCA1; the disease is breast cancer.