The lifetime cumulative risk of ovarian cancer for BRCA1 carriers was estimated to be 36.9% (95% CI: 23.4–53.9%): 39.7% (95% CI: 16.6–72.8%) in region 1, 28.1% (95% CI: 12.1–55.8%) in region 2, and 44.4% (95% CI: 19.9–76.0%) in region 3 (Figure 3c, Supplementary Table S13). This evidence concerns the gene BRCA1 and ovarian cancer.