The cumulative lifetime risk of breast cancer for BRCA1 carriers was 59.1% (95% CI: 44.1–73.6%): 64.4% (95% CI: 37.8–87.1%) in region 1 (~c.2281, BCCR), 43.4% (95% CI: 22.4–69.8%) in region 2 (c.2282 to c.4071, OCCR), and 67.3% (95% CI: 41.1–88.3%) in region 3 (c.4072~, BCCR) (Figure 3c, Supplementary Table S13). The gene discussed is BRCA1; the disease is breast cancer.