Furthermore, multivariable logistic regression analysis with AKI as the dependent variable was performed to identify independent factors (preoperative and intraoperative data), as shown in Table 4B. The risk of developing AKI increased with increasing preoperative ET-1 level at baseline (OR for 1 pg/mL increase in ET-1, 2.177; 95% CI, 1.034–4.584; p = 0.041) and CPB time (OR for 1 h increase in CPB time, 4.194; 95% CI, 2.005–8.773; p < 0.000), even adjusted by age, sex, and BMI. The gene discussed is EDN1; the disease is acute kidney injury.