Plasma natriuretic peptides such as brain natriuretic peptide (BNP) and N-terminal fragment BNP (NT-proBNP) have already been established in the diagnostic algorithm of HF, while other serum biomarkers such as soluble interleukin 1 receptor-like 1 (ST2), galectin-3 (Gal-3), copeptin, adrenomedullin, high sensitivity troponin (hsTn), growth differentiation factor 15 (GDF-15), adiponectin, C-reactive protein (CRP) and neprilysin have been tested without definite evidence yet to recommend them for clinical practice [1,6,7,8,9,10,11,12,13,14,15,16,17]. Here, IL1RL1 is linked to hydrops fetalis.