Bhardwaj et al. utilized AREG, MASP1, OPN, PON3, and TR with the least absolute shrinkage and selection operator (LASSO) and achieved an AUC of 0.86 (with a sensitivity of 83% and a specificity of 80%) in diagnosing early-stage CRC [53]. This evidence concerns the gene PON3 and colorectal carcinoma.