PON3 and colorectal carcinoma: In another study from Bhardwaj et al., they combined HP, LRG1, and PON3 with LASSO and achieved an AUC of 0.83 (with a sensitivity of 67% and a specificity of 80%) in diagnosing early-stage CRC; they also utilized eight biomarkers with LASSO and achieved an AUC of 0.96 (with a sensitivity of 93% and a specificity of 80%) in diagnosing late-stage CRC [54].