Furthermore, DC-SIGNR can also interact with angiotensin-converting enzyme 2 (ACE2), a known cellular receptor for SARS-CoV-2 infection, suggesting a possible role for heterodimerization DC-SIGNR and ACE2 in SARS-CoV-2 entry and infection in cell types where both are present [230]. The gene discussed is CLEC4M; the disease is infection.