Accordingly, a cytotoxic effect of CBD was observed in several cell lines including estrogen-receptor (ER)-positive cells (MCF-7, ZR-75-1, T47D), ER-negative cells (MDA-MB-231, MDA-MB-468, and SK-BR3), and triple-negative breast cancer cells (SUM159, 4T1up, MVT-1, and SCP2) [115,116,117,118,119]. The gene discussed is ESR1; the disease is triple-negative breast carcinoma.