PCNA and cancer: Regarding HBV and cancer, Feng investigated the roles of lncRNA proliferating cell nuclear antigen pseudogene 1 (PCNAP1 )in the contribution of HBV replication through the modulation of miR-154/PCNA/HBV cccDNA signaling in hepatocarcinogenesis using CRISPR/Cas9, and as results the expression levels of PCNAP1 and PCNA were significantly elevated in the liver of HBV-infectious human liver-chimeric mice [135].