Notably, for HPV, it has been reported that RNAi targeting of E7 or E6/E7 promotes the accumulation of TP53 and/or pRB, eventually leading to the induction of apoptosis and/or senescence in HPV16-positive cervical cancer cell lines (JIANG; MILNER, 2002 [118]; SIMA [119,120]), as well as, in HPV18-positive human cervical cancer cells [121,122]. This evidence concerns the gene TP53 and cervical cancer.