These results suggest that besides the Apc truncation, lack of other Wnt/β-catenin signaling inhibitors contribute to the modulation of β-catenin in the colon of ApcMin/+ mice; and also that the diets supplemented with either probiotics or probiotics plus quercetin exerted their protective action against colon cancer development by inhibiting the canonical Wnt/β-catenin signaling pathway, thus reducing β-catenin degradation and regulating microtubule stabilization. The gene discussed is APC; the disease is colonic neoplasm.