Recently, Peng et al. demonstrated that patients with mastocytosis had enhanced NT levels and the elevated expression of TRKs on MCs in the skin and gut, and NGF increased the migration of KIT+ cells from the blood via TRKA, suggesting that TRK signaling might contribute to mastocytosis pathogenesis through autocrine and paracrine loops [40]. This evidence concerns the gene NTRK1 and mastocytosis.