Some TRK inhibitors are currently being tested in clinical trials, and entrectinib and Larotrectinib (LOXO-101) have been approved for use in patients with TRK fusion-positiv solid tumors, demonstrating that some human cancers are TRK dependent and that TRKs may be good targets for molecular therapy [33,34,35]. The gene discussed is NTRK1; the disease is cancer.