VEGFA and polycystic ovary syndrome: In a randomized placebo-controlled trial that examined effects of vitamin D versus placebo administration in vitamin D deficient women with PCOS, Irani et al. [110] demonstrated significant reduction in serum VEGF levels in the group supplemented with vitamin D compared to placebo (1106.4 ± 36.5 to 965.3 ± 42.7 pg·mL−1; p < 0.001) (Figure 6).