INS and polycystic ovary syndrome: Advani et al. showed that 12-week supplementation with insulin sensitizing agents (the inositol isomers myo-inositol (MI) and D-Dhiro-inositol (DCI) and chromium picolinate), plus antioxidants (N-acetyl cysteine and lycopene) and vitamins (including vitamin D, biotin and folic acid) was associated with regular menstrual cycles, improved hirsutism and significant reduction the BMI in obese patients with PCOS compared to baseline [91].