It also facilitates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)- and Bcl-2 inhibitor-induced apoptosis in GBM cells through Noxa expression, sequestration of Mcl-1 by Noxa, and delivery of pro-apoptotic protein Bim and Bak from Mcl-1 [127,128]. The gene discussed is MCL1; the disease is glioblastoma.