The observation that IL-8 and leptin levels correlated with BMI, but not age and that IL-3, IL-7, IL-15, TGFβ1, TGFβ3, and MIP-1 levels correlated with age, but not BMI suggest distinct fibroinflammatory responses in obesity and aging, and thereby unique mechanisms by which these factors negatively impact oocyte quality. Here, CXCL8 is linked to obesity due to melanocortin 4 receptor deficiency.