Men who smoked and had insomnia had reduced E2 levels (β = −2.06, 95% CI: −4.09, −0.02; p = 0.048), while those who smoked and did not get enough sleep time were associated with increased LH levels—by 0.89 IU/L (95% CI: 0.14, 1.64). Here, PLOD1 is linked to insomnia.