The underlying biological assumptions of our model were that, in the context of a non-tumorigenic TME, the ECM remains soft, growth factors (HGF and EGF), inflammatory signals (IL6, TGFB and ROS), DELTA and WNT are absent, whereas the RPTP ligand (RPTP_L) is present, as RPTPs display tumour suppressive capabilities [56]. Here, EGF is linked to neoplasm.