PDCD1 and cancer: Fractionated radiotherapy combined with chemotherapy (radiochemotherapy) increased PD-L1 expression on glioblastoma cells, but has no significant impact on PD-L1 expression in colorectal cancer cells, showing that efficacy of combination therapy with anti-PD1/PD-L1 ICBs and radiochemotherapy depends on cancer type and chemotherapeutic drug type [91].