LEP and Insulin resistance: Central adiposity, especially in female patients, is considered one of the major drivers of cardiometabolic risk, characterized by increased markers of inflammation (IL-1β, IL-6, TNF-receptors 1 and 2), insulin resistance (homeostasis model assessment of insulin resistance), and increased adipokine levels (adiponectin, total and high molecular weight, resistin and leptin), all factors that contribute to inflammation with the impairment of renal function and mortality [33].