On the other hand, studies of our group in a nutritional setting evaluated the action of α-lipoic acid (ALA) daily supplementation in patients with autosomal dominant polycystic kidney disease (ADPKD), demonstrating a significant improvement of metabolic, inflammatory, endothelial dysfunction, and OS indexes, namely the amelioration of serum glucose and uric acid, CRP, renal resistive index, and NADPH oxidase 2 (NOX2), with the aim to counteract the abnormal increase of OS and inflammatory status [103]. The gene discussed is CYBB; the disease is endothelial dysfunction.