CYBB and endothelial dysfunction: In these cases, a significant improvement of metabolic, inflammatory, and endothelial dysfunction indexes was reached, with a significant improvement in NADPH oxidase 2 (NOX2), as confirmed by the monitoring in these cohorts patients of CRP, erythrocyte sedimentation rate, early erythrocyte glutathione-transferase, and human oxidized serum albumin [102,103].