TRPV1 and temporal lobe epilepsy: In 2010, Bhaskaran and Smith conducted a pioneering study demonstrating that TRPV1 expression was significantly higher in the dentate gyrus of mice with Temporal lobe epilepsy (TLE) compared with control mice and also that anandamide, an endocannabinoid endowed with an intrinsic agonist activity on TRPV1, enhanced glutamate release [86].