The NLRP3 inflammasome is a central regulator of inflammation and its activation has been associated with several age-related diseases, such as Alzheimer’s disease, atherosclerosis, Parkinson’s disease, and age-related macular degeneration (AMD) [1,3,4,5,6,7,8,9,10]. The gene discussed is NLRP3; the disease is age-related macular degeneration.