COL12A1 and Ehlers-Danlos syndrome: Furthermore, a connection between mutations in COL12A1 and Ehlers–Danlos Syndrome (EDS) has also been demonstrated [18]; whereas a major part of EDS symptomatology is strictly connected with GJH and hyper elastic skin, TMJ posterior band ligaments, which are primarily composed of collagen fibers defined by a certain length, have also been shown to play a significant role in preventing TMJ disc displacement [19].