ATRX and glioblastoma: For instance, it was recently showed that ATRX knockout in GBM cells triggers [81] an impoverishment of H3K27me3 in FADD (Fas-associated death domain) promoter region, suggesting that the ATRX/EZH2 complex promoted trimethylation of histone H3K27 in this region, thus silencing it [82].