In hepatic carcinomas, exosomes released from hepatic CSCs were found to exert protumorigenic and prometastatic effects by altering the expression of the targeted molecules p53, BCL-2, vascular endothelial growth factor (VEGF), TGF-β, and matrix metalloproteinase (MMP)-9 [46]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.