GLA and Fabry disease: Fabry disease is a lysosomal storage disease with an X-linked recessive inheritance caused by variants in the GLA gene, that determine an absent or deficient activity of lysosomal alpha galactosidase A. As a result, globotriaosylceramide accumulate within virtually all cell types’ lysosomes, leading to cellular death, inflammation, oxidative stress, and fibrosis; cardiomyocyte hypertrophy results from increased concentrations of sphingolipid and vascular smooth muscle cell proliferation [79].