IKZF1 deletions are significantly more common in patients carrying kinase or cytokine receptor rearrangement (IGH-CRLF2) than a sequence mutation [4,13], especially in Hispanic/Latino (H/L) children with B-ALL (29% in H/L compared to 15% of non-Hispanic Whites) where both IGH-CRLF2 translocation and IKZF1 deletion provide a strong biological rationale for the higher death-rate H/L experience due to B-ALL [60]. This evidence concerns the gene CRLF2 and acute lymphoblastic leukemia.