Around 5% of Ph-like ALL cases harbor gene fusions or mutations involving NTRK3, BLNK, DGKH, PTK2B, FLT3, FGFR1, TYK2 and SH2B3. Among those, one percent of cases harbor the fusion between ETV6 and NTRK3 encoding a member of the tropomyosin receptor tyrosine kinase (TRK) family [51]. This evidence concerns the gene NTRK3 and acute lymphoblastic leukemia.