SQSTM1 and osteosarcoma: In addition, the ICP0 protein downregulates SLR autophagy receptors p62/SQSTM1 and OPTN during the early stages of HSV-1 infection in various cell lines, including human embryonic lung fibroblasts (HEL), human epithelial cells (HEp-2), human microglia cell line 3 (HMC3), human osteosarcoma cell line (U2OS), but not human monocyte cell line (THP1) [125].