SNCA and Parkinson disease: From a neuropathological point of view, PD is characterized by a selective degeneration of dopaminergic neurons in the pars compacta region of the substantia nigra (SNc) and by the cytoplasmic and axonal accumulation of aggregated misfolded α-synuclein into Lewy bodies (LB) and Lewy neurites (LN) [63].