G6Pase, AdipoR, IGF1R, INSR, and INSRR were predicted to be targeted by DE-tsRNAs (Data Supplement IV); particularly, tsRNA-Glu-CTC-003 targeted G6PC2 and tsRNA-Val-AAC-017 targeted IGF1R were both differentially altered in the mRNA sequencing results (Figure 4 and Data Supplement V and VI), which jointly pointed to the conclusion drawn from a previous study, in which an elevated supply of energy protected patients with MMD from brain dysfunction [29]. The gene discussed is INSR; the disease is multiminicore myopathy.