To prove that MG-induced responses as well as OP protective role against them occurred through Nrf2/Glo1 axis, we pretreated cells with a Nrf2 activator (Nrf2-A) [42], before exposing them to MG and OP, and evaluated Glo1 expression, MG-H1 intracellular or released levels, caspase-3 activation and tubule formation. The gene discussed is GLO1; the disease is myasthenia gravis.