TAT with 225Ac-PSMA-617 demonstrated tumour growth inhibition at activities of 0.02, 0.04 and 0.10 MBq in a radiosensitive model (Table S1) [59] However, mice treated with 0.10 MBq experienced toxicity, including severe weight loss, while mice treated with 0.02 and 0.04 MBq experienced transient weight loss. The gene discussed is FOLH1; the disease is neoplasm.