In particular, the evaluation of the frequencies of protein-specific CD4+ and CD8+ memory T cells in the immunocompetent patients with primary CMV infection showed that proteins gB and pp65 were immunodominant targets of memory CD4+ T cells, and IE-1 protein and pp65 were immunodominant targets of CD8+ T cells; the pattern of T cell reactivity was comparable at early and late stages of infection. This evidence concerns the gene CD4 and infection.