Recently, Mele and colleagues analyzed the frequencies of CD4+ and CD8+ T cells specific for four CMV proteins, IE-1, pp65, gHgLpUL128L (pentamer) and gB, in the memory pool of six immunocompetent patients with primary CMV infection (within one month and at 6–12 months after infection onset (at early and late stages of infection, respectively)) [14]. The gene discussed is CD8A; the disease is infection.