Some abnormal subregions and pathogenic genes associated with AD were detected in our research, such as hippocampus amygdala transition area (HATA), fimbria, parasubiculum, hippocampal fissure and RYR3 and PRKCE. The HATA was connected with the amygdala closely, and compared with the healthy group, the volumes of HATA were reduced in the MCI group [2,38]. This evidence concerns the gene PRKCE and Alzheimer disease.