The CORACLE Registry confirmed the negative prognostic role of older age, cardiovascular diseases, COPD, immunosuppression, diabetes, patients presenting with an eGFR < 30 mL/min/1.73 m2, high values of CRP and a low PaO2/FiO2 ratio upon admission of COVID-19 patients on hospital mortality. The gene discussed is CRP; the disease is COVID-19.