MAP2K7 and neoplasm: The development of these tumours is mediated through TSH-independent growth, TSH-dependent apoptosis, DNA damage and de-differentiation, mainly through the RAF/MEK/ERK pathway, stress-activated protein kinase (SAPK)/JNK pathway (apoptosis), and unknown pathway/s involved in RAS-induced dedifferentiation through inhibition of TTF-1 and/or PAX-8.