In addition to TSHR, numerous tumour suppressor genes silenced through aberrant methylation include genes encoding cyclin-dependent kinase inhibitors p15INKa and p16INK4b [139], RASSF1A [140], RARβ-2(retinoic acid receptor β-2), ECAD, NIS-I, ATM, DAPK (death-associated protein kinase), TIMP3 (tissue inhibitor of metalloproteinase-3), SLC26A and SLC5A8 (sodium monocarboxylate transporter) [141,142]; the latter four are associated with aggressive features. Here, TIMP3 is linked to neoplasm.