Likewise, treatment with the anti-Dickkopf 1 (DKK1, antagonist of the Wnt/β-catenin signaling pathway), BHQ880, reduces osteosarcoma development and lung metastasis in mouse models of patient-derived osteosarcoma xenograft [26], supporting a tumor suppressor role of β-catenin in osteosarcoma. This evidence concerns the gene DKK1 and neoplasm.