AGMO and obesity due to melanocortin 4 receptor deficiency: AGMO is localized in the membrane of the endoplasmic reticulum (ER) and was, therefore, originally named transmembrane protein 195, TMEM195 [26], which gained some attention, because genome-wide association studies (GWS) identified polymorphisms in the intergenic region of diglycerol kinase beta (DGKB) and TMEM195 in association with type 2 diabetes and obesity [27,28,29,30,31].