Indeed, MTUS1 down-regulation in cancer tissues was frequently reported, including in tumors from the breast [19,20,21,22,23], bladder [24,25], colon [26,27,28,29], gallbladder [30], gastric tissues [31,32], lung (NSCLC) [33], head-and-neck [34,35,36,37,38,39], clear cell renal cell carcinoma (cc-RCC) [40,41], and uveal melanoma [42], with the exception of prostate cancer, in which MTUS1 expression was reported to increase with cancer progression [43,44] (Table 1). Here, MTUS1 is linked to clear cell renal carcinoma.