MTUS1 and breast cancer: In a transcriptomic analysis of three independent cohorts of breast cancer patients treated in neo-adjuvant settings with taxanes, 17 genes encoding microtubule-regulating proteins were found differentially expressed in chemoresistant breast tumors [58], and one of the most strongly deregulated genes was MTUS1. Interestingly, ATIP3 expression was significantly down-regulated in taxane-sensitive tumors achieving pathological complete response to chemotherapy [58], including in the BL1 subtype of TNBC [77].