Additionally, combing LDC0000167 with the BRD4 inhibitors-JQ1 or iBET-762 against malignant rhabdoid tumors, down-regulated the anti-apoptotic genes MCL-1, BCL-6 and BTG1 as well as MYC and inhibited cell-proliferation and tumor growth in vitro and in vivo [170]. The gene discussed is BRD4; the disease is neoplasm.