Fourteen other mammalian RAS GAPs have been discovered ever since, including neurofibromin 1 (NF1, the protein responsible for neurofibromatosis type 1, which is also a RAS GAP closely related to the Saccharomyces IRA proteins) [61], the GAP1 family (GAP1m/RASA2, GAPIP4BP/RASA3, CAPRI/RASA4 and RASAL1) and the SynGAP family (SynGAP, DAB2ip, RASAL2 and RASAL3) (rev. This evidence concerns the gene SYNGAP1 and neurofibromatosis type 1.