In an in vitro study of GBM, LCN2 expression correlated negatively with malignancy and resistant to chemotherapy; additionally, the transfection of BCNU-resistant variant glioma cells with LCN2 cDNA resulted in apoptotic sensitivity and chemosensitivity through inhibition of the Akt signaling pathway [6]. This evidence concerns the gene AKT1 and central nervous system cancer.