CXCL12 and obesity due to melanocortin 4 receptor deficiency: In the multivariate analysis, after adjusting for age, sex, DM, hypertension, dyslipidaemia, smoking, obesity, alcohol intake, and PREDIMED score (Table 4), both SDF1 [OR (95%CI): 2.4 (1.5–3.9) p < 0.001] and CRP [OR (95%CI): 1.6 (1.3–2.0, p < 0.001)] remained independently associated with clinical atherosclerosis.