CD4 and type 1 diabetes mellitus: In type I diabetes (T1D), the highly upregulated miR-142-3p in CD4+ T cells from human patients and a murine model of T1D interfered with the induction of regulatory T (Treg) cells by targeting TET2, which enhanced the methylation at the conserved non-coding DNA sequence element 2 (CNS2) of the Foxp3 gene [95].