The miRNA profiling studies have also identified the upregulation of miRNAs from the Dlk1-Dio3 locus in human lupus PBMCs (miR-134, miR-382, miR-409, miR-411, miR-493, miR-494, miR-544, and miR-654) [74,76], in circulating blood of patients with class IV lupus nephritis (miR-485-5p, miR-543, miR-410-3p, and miR-369-5p) [123], in the renal biopsy samples of the patients with lupus (miR-134, miR-433, and miR-494) [37,124], and in the lesioned skin biopsy samples of the patients with discoid cutaneous lupus (miR-485-3p) [125]. Here, DLK1 is linked to systemic lupus erythematosus.