DIO3 and cancer: The Dlk1-Dio3 miRNAs have been implicated in the pathogenesis of cancers via targeting key genes in cancer biology, such as phosphatase and tensin homolog (PTEN) [131] and mesenchymal-epithelial transition factor (c-Met) [115], and tumorigenesis signaling pathways such as PI3K/AKT [132], Hippo signaling, and p53 signaling [116].