Further, we found that in vitro inhibition of specific Dlk1-Dio3 miRNAs such as miR-154, miR-379, and miR-300 in MRL-lpr splenocytes suppressed the production of LPS-induced, lupus-related cytokines such as IFNγ, IL-1β, IL-6, and IL-10 [98]. The gene discussed is DIO3; the disease is systemic lupus erythematosus.