The overall DNA hypomethylation and robust DNA demethylation of IFN signature genes such as MX1, IFI44L, interferon induced transmembrane protein 1 (IFITM1), Poly(ADP-ribose) polymerase family member 9 (PARP9), IFIT3, DExD/H-Box helicase 60 (DDX60), lymphocyte antigen 6 family member E (LY6E), and interferon-stimulated gene 15 (ISG15) has also been identified in lupus neutrophils [51]. This evidence concerns the gene PARP9 and systemic lupus erythematosus.