DIO3 and systemic lupus erythematosus: In addition to the lpr lupus model, the upregulation of selected Dlk1-Dio3 miRNAs has also been observed in the splenocytes of the other murine lupus murine models, NZBWF1 mice [77] and C3.MRL-Faslpr/J mice [122] (miR-127 and miR-379).