IRAK3 and systemic lupus erythematosus: In addition, the hypomethylation TLR signaling pathway genes such as eukaryotic translation initiation factor 2 α kinase 2 (EIF2AK2) and interleukin 1 receptor associated kinase 3 (IRAK3) in lupus peripheral blood mononuclear cells (PBMCs), which correlated with the enrichment of differentially expressed genes involved in IFN and TLR signaling pathways, has also been reported [52].