CRKL and systemic lupus erythematosus: In addition, miR-30a [80], miR-1246 [81], miR-29a [82], and miR-7, miR-21, and miR-22 [83] have also been reported to be dysregulated in human lupus B cells, which contribute to abnormal B cell activity in lupus via the targeting of different key signaling molecules involved in B cell development and activation such as tyrosine-protein kinase Lyn, early B-cell factor 1 (EBF1), Crk-like protein (CRKL), or phosphatase and tensin homolog (PTEN).