Our previous miRNA microarray profiling study identified that selected miRNAs from the Dlk1-Dio3 locus were significantly upregulated in lupus cells, which included miR-127, miR-154, miR-299, miR-300, miR-329, miR-376b, miR-379, miR-382, miR-411, miR-433, and miR-494 [77,98]. Here, DIO3 is linked to systemic lupus erythematosus.