The occurrence of hypertensive disorder complicating pregnancy can be caused by the decrease of the expression of MMP9 in the network [48], and AKT1 [49], ESR1 [50], FOS [51], VEGFA [52] and other proteins play an important role in the pathogenesis of hypertensive disorder complicating pregnancy, such as preeclampsia. The gene discussed is ESR1; the disease is preeclampsia.