Among the first pieces of evidence, Ma et al. reported that BPA oral exposure (50 μg/kg/day) during nursing and gestation in Wistar rats induced IR, glucose intolerance, and increased body weight in the 21st week of pregnancy by promoting hepatic DNA global hypomethylation as well as glucokinase (gck) gene hypermethylation, which codifies a glycolysis rate-limiting enzyme, essential in hepatocyte glucose utilization. The gene discussed is GCK; the disease is Glucose intolerance.