Similarly, other EDCs such as NP can exert significant effects on MMP loss and apoptosis of rat hepatocytes by promoting an increase in uncoupling protein-2 (UCP2) [109], deregulating Bax/Bcl-2 activity, and triggering mRNA activation of TNF-α, caspase-9, and Fas/FasL [110], thus promoting the development of mitochondrial dysfunction, liver injury, and steatosis. This evidence concerns the gene TNF and steatosis.