TNF and steatosis: On the other hand, DEPH has been associated with hepatic fibrosis and pro-inflammatory phenomena as a result of observable increments in steatosis, hepatocyte necrosis, and immune infiltration after TNF-α and IL-6 increments following different doses of DEPH in addition to increased levels of profibrogenic factors such as α-SMA, COL-I, COL-III, and TGF-β1 in LX-2 cells [136].