Cases with MYC gain and PTEN loss were also more likely to have cribriform Gleason pattern 4 carcinoma (>200 μm) at biopsy by logistic regression (OR, 8.85; 95% CI, 2.96–27.82; P = 0.0001 for combined PTEN loss and MYC gain) (Supplemental Table S4). This evidence concerns the gene MYC and carcinoma.