PTEN and cribriform carcinoma: In a homogeneous cohort of Grade Group 2 biopsy samples from patients who underwent subsequent radical prostatectomy, the AUC for a baseline model using the preoperative variables from standard preoperative risk calculators was found to be increased from 0.68 to 0.69 with the inclusion of intraductal or cribriform carcinoma status and to 0.75 with the inclusion of MYC/PTEN status.