By log-rank analysis, the presence of intraductal carcinoma at biopsy (P = 0.012), cribriform Gleason pattern 4 carcinoma at biopsy (P = 0.007), and PTEN loss at biopsy (P = 0.014) were significantly associated with decreased time to recurrence (Figure 2A-C). This evidence concerns the gene PTEN and carcinoma.