MYC gain and PTEN loss were significantly associated with the presence of intraductal carcinoma at biopsy by logistic regression analyses (OR, 13.33; 95% CI, 3.85–49.67; P < 0.0001 for combined MYC gain and PTEN loss) (Supplemental Table S3). The gene discussed is MYC; the disease is ductal breast carcinoma in situ.