PTEN and Familial prostate cancer: ,8 The loss of the tumor suppressor PTEN is one of the most common alterations found in primary prostate cancer, and it is reproducibly associated with worse prognosis in numerous studies.10, 11, 12, 13,27, 28, 29, 30, 31MYC or 8q amplification is another independent predictor of tumor progression, particularly in the setting of Grade Group 2 or 3 cancer.14