Considering that TP53 mutations are mutually exclusive with HPV infection in HNSCC, and that these two types of tumors (TP53mut/HPV− and TP53wt/HPV+) might respond very differently to CTX+RT, the role of miR‐9 and this double‐faced behavior of KLF5 may represent very a relevant evidence that will need further exploration (Leemans et al,2011). Here, KLF5 is linked to head and neck squamous cell carcinoma.