APOE and obesity due to melanocortin 4 receptor deficiency: For instance, according to the parameters estimated by this multi-adjusted model, in 80-year-old participants from Bordeaux without comorbidity (obesity, hypertension, diabetes, depression) and without ApoE allele 4, the mean IST decline was 0.90 word per year in the low-level and 0.69 word per year in the high-level household/transportation PA group.