Although ALS1 and HWP1 are considered reliable markers of Candida virulence and are overexpressed in the pathogenic organism causing several diseases (i.e vulvovaginitis, periodontal diseases), an increase of their expression in CI1 did not manifest itself as an increase in virulence and aggressivity of the fungus in the G. mellonella assay, indicating that they are necessary for a virulent behavior of the parasite but in these cases their overexpression is not positively correlated with lethality. Here, SOD1 is linked to periodontal disorder.