Multinomial regression analysis showed a significant contribution of sleeping hours in AMD progression along with existing factors like smoking, alcohol, food habit etc. Temporal protein expressions in differential environmental exposure indicate the plausible role of epigenetics in AMD which has been evident by the 48% higher activity of DNA methyltransferases (DNMTs) in addition to enhanced DNMT1 and DNMT3B levels in AMD as compare to controls. This evidence concerns the gene DNMT3B and age-related macular degeneration.