Regression analysis shows that night sleeping hours (B = 0.449; Exp(B) = 1.567; 95% CI = 1.1–2.23; P = 0.013) along with the expression of IER3 (B = -.444; Exp(B) = 0.641; 95% CI = 0.512–0.804; P = <0.0001) and TIMP3 (B = -23.54; Exp(B) = <0.0001; 95% CI = 0.000–0.004; P = 0.010) are significantly associated with AMD pathology. This evidence concerns the gene IER3 and age-related macular degeneration.