In our earlier report, smoking was found to be associated with TC genotype of CFH variant (Y402H) along with marginal association of AG genotype of TLR3 (rs3775291) with non-vegetarian food habit which also exhibited confounding effect on CFH expression and modulated TLR3 mediated functions in AMD [32, 33]. This evidence concerns the gene TLR3 and age-related macular degeneration.