Significant changes in IER3 (B = -.314; 95% CI = .637-.838; P = <0.0001), TIMP3 (B = -41.969; P = <0.0001) and SLC16A8 (B = -0.184; 95% CI = 1.022–1.415; P = 0.027) expression were observed while adjusting the physical activity of AMD patients (Table 4). The gene discussed is TIMP3; the disease is age-related macular degeneration.