The beta coefficient (B) of logistic regression analysis revealed that significantly decreased expression of IER-3 (-0.288), B3GALTL (-0.214), LIPC (-0.172), TIMP-3 (-63.696) along with increased levels of HTRA1 (0.696) were observed in Indian AMD, without adjusting the ADL. This evidence concerns the gene HTRA1 and age-related macular degeneration.