We report that there is an alteration in expressions of HtrA Serine Peptidase 1 (HTRA1), Tissue inhibitor of metalloproteinase-3 (TIMP-3) and Immediate Early Response 3 (IER-3) in sleep deprived individuals or AMD patients with increase in sleep duration, prompting further research [24, 25]. The gene discussed is HTRA1; the disease is age-related macular degeneration.