CD4 and heart disorder: The ratio of CD4+ and CD8+ T cells expressing the IL-27R components before and after T. cruzi infection in vitro in the group of patients with heart disease symptoms (i.e., the G1/G2 group) was significantly lower than that in G0 and uninfected subjects (Fig 2A G1/G2 vs. UI P = 0.012, G1/G2 vs. G0 P = 0.005; Fig 2D G1/G2 vs. UI P = 0.002, G1/G2 vs. G0 P = 0.005).