Patients without heart disease (i.e., the G0 group) had a decreased frequency of antigen-experienced CD4+ T cells expressing both chains of IL-27R (Fig 1A), with a reciprocal increase in the frequency of CD4+CD45RA—WSX-1—CD130+ T cells, (Fig 1B), compared with uninfected subjects. This evidence concerns the gene IL27RA and heart disorder.