In the longitudinal analysis, similar associations of cognitive decline with lifestyle profile and APOE genotypes were observed in the adjusted model (S2 Table) (healthy versus unhealthy lifestyle: OR: 0.72, 95% CI: 0.54, 0.95, P = 0.033; APOE ε4 noncarrier versus carrier: OR: 0.75, 95% CI: 0.60, 0.94, P = 0.027). Here, APOE is linked to Mental deterioration.