In the subgroup analyses by APOE genotype, among APOE ε4 noncarriers, the odds of cognitive impairment in participants with a healthy lifestyle was lower than that in those with an unhealthy lifestyle (OR: 0.47, 95% CI: 0.37 to 0.60, P < 0.001) (Fig 2). Here, APOE is linked to Cognitive impairment.