To investigate the organ protection benefits of SGLT-2 inhibitors in COVID-19, an ongoing international, multicenter, randomized clinical study is evaluating dapagliflozin compared with placebo in prevention of COVID-19 complications or death and improvement of clinical recovery (Dapagliflozin in Respiratory Failure in Patients with COVID-19, DARE-19; https://clinicaltrials.gov NCT04350593). Here, SLC5A2 is linked to COVID-19.